Posts Tagged ‘animation’

Caesium trifluoride: could it be made?

Saturday, November 23rd, 2013

Mercury (IV) tetrafluoride attracted much interest when it was reported in 2007[1] as the first instance of the metal being induced to act as a proper transition element (utilising d-electrons for bonding) rather than a post-transition main group metal (utilising just s-electrons) for which the HgF2 dihalide would be more normal (“Is mercury now a transition element?”[2]). Perhaps this is the modern equivalent of transmutation! Well, now we have new speculation about how to induce the same sort of behaviour for caesium; might it form CsF3 (at high pressures) rather than the CsF we would be more familiar with.[3] Here I report some further calculations inspired by this report.

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References

  1. X. Wang, L. Andrews, S. Riedel, and M. Kaupp, "Mercury Is a Transition Metal: The First Experimental Evidence for HgF4", Angew. Chem. Int. Ed., vol. 46, pp. 8371-8375, 2007. http://dx.doi.org/10.1002/anie.200703710
  2. W.B. Jensen, "Is Mercury Now a Transition Element?", J. Chem. Educ., vol. 85, pp. 1182, 2008. http://dx.doi.org/10.1021/ed085p1182
  3. M. Miao, "Caesium in high oxidation states and as a p-block element", Nature Chem, vol. 5, pp. 846-852, 2013. http://dx.doi.org/10.1038/nchem.1754

Why is the Sharpless epoxidation enantioselective? Part 1: a simple model.

Sunday, December 9th, 2012

Sharpless epoxidation converts a prochiral allylic alcohol into the corresponding chiral epoxide with > 90% enantiomeric excess[1],[2]. Here is the first step in trying to explain how this magic is achieved.

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References

  1. J.M. Klunder, S.Y. Ko, and K.B. Sharpless, "Asymmetric epoxidation of allyl alcohol: efficient routes to homochiral .beta.-adrenergic blocking agents", J. Org. Chem., vol. 51, pp. 3710-3712, 1986. http://dx.doi.org/10.1021/jo00369a032
  2. R.M. Hanson, and K.B. Sharpless, "Procedure for the catalytic asymmetric epoxidation of allylic alcohols in the presence of molecular sieves", J. Org. Chem., vol. 51, pp. 1922-1925, 1986. http://dx.doi.org/10.1021/jo00360a058

Molecular gymnastics in 2+2 cycloadditions.

Wednesday, December 14th, 2011

In this earlier post, I described how the stereochemistry of π22 cycloadditions occurs suprafacially if induced by light, and how one antarafacial component appears if the reaction is induced by heat alone. I also noted how Woodward and Hoffmann (WH) explained that violations to their rules were avoided by mandating a change in mechanism requiring stepwise pathways with intermediates along the route. Here I illustrate how the stereochemistry of a thermal π22 cycloaddition can indeed avoid an antarafacial component by performing appropriate gymnastic contortions instead of a mechanistic change (a WH violation certainly in the letter of their law, if not their spirit).
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The chemistry behind a molecular motor. The four wheels?

Friday, November 25th, 2011

In the previous post, I wrote about the processes that might be involved in a molecular wheel rotating. A nano car has four wheels, and surely the most amazing thing is how the wheels manage to move in synchrony. This is one hell of a tough problem, and I do not attempt an answer here, but simply record an odd observation.

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Atropisomerism in Taxol. An apparently simple bond rotation?

Tuesday, November 1st, 2011

My previous post introduced the interesting guts of taxol. Two different isomers can exist, and these are called atropisomers; one has the carbonyl group pointing up, the other down. The barrier to their interconversion in this case is generated by a rotation about the two single bonds connecting the carbonyl group to the rest of the molecule. Introductory chemistry tells us that the barrier for rotation about such single bonds is low (i.e. fast at room temperature). But is that true here?

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Mechanism of the reduction of a carboxylic acid by borane: revisited and revised.

Sunday, October 16th, 2011

I asked a while back whether blogs could be considered a serious form of scholarly scientific communication (and so has Peter Murray-Rust more recently). A case for doing so might be my post of about a year ago, addressing why borane reduces a carboxylic acid, but not its ester, where I suggested a possible mechanism. Well, colleagues have raised some interesting questions, both on the blog itself and more silently by email to me. As a result, I have tried to address some of these questions, and accordingly my original scheme needs some revision! This sort of iterative process of getting to the truth with the help of the community (a kind of crowd-sourced chemistry) is where I feel blogs do have a genuine role to play.

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Less is more: the dyotropic rearrangement of ethane

Saturday, June 11th, 2011

In a time when large (molecules) are considered beautiful (or the corollary that beauty must be big), it is good to reflect that small molecules may teach us something as well. Take ethane. Is there anything left which has not been said about it already? Well, consider the reaction below, in which two hydrogen atoms mutually hop from one carbon to the other.

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Do electrons prefer to move in packs of 4, 6 or 8 during proton exchange in a calixarene?

Friday, January 7th, 2011

This story starts with a calixarene, a molecule (suitably adorned with substituents) frequently used as a host to entrap a guest and perchance make the guest do something interesting. Such a calixarene was at the heart of a recent story where an attempt was made to induce it to capture cyclobutadiene in its cavity.

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Rate enhancement of the Diels-Alder reaction inside a cavity

Saturday, October 30th, 2010

Reactions in cavities can adopt quite different characteristics from those in solvents. Thus first example of the catalysis of the Diels-Alder reaction inside an organic scaffold was reported by Endo, Koike, Sawaki, Hayashida, Masuda, and Aoyama (DOI: 10.1021/ja964198s), where the reaction shown below is speeded up very greatly in the presence of a crystalline lattice of the anthracene derivative shown below.

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The oldest reaction mechanism: updated!

Tuesday, September 14th, 2010

Unravelling reaction mechanisms is thought to be a 20th century phenomenon, coincident more or less with the development of electronic theories of chemistry. Hence electronic arrow pushing as a term. But here I argue that the true origin of this immensely powerful technique in chemistry goes back to the 19th century. In 1890, Henry Armstrong proposed what amounts to close to the modern mechanism for the process we now know as aromatic electrophilic substitution [1]. Beyond doubt, he invented what is now known as the Wheland Intermediate (about 50 years before Wheland wrote about it, and hence I argue here it should really be called the Armstrong/Wheland intermediate). This is illustrated (in modern style) along the top row of the diagram.

The mechanism of aromatic electrophilic substitution

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References

  1. "Proceedings of the Chemical Society, Vol. 6, No. 85", Proceedings of the Chemical Society (London), vol. 6, pp. 95, 1890. http://dx.doi.org/10.1039/pl8900600095