The mechanism of the Baeyer-Villiger rearrangement.

The Baeyer-Villiger rearrangement was named after its discoverers, who in 1899 described the transformation of menthone into the corresponding lactone using Caro’s acid (peroxysulfuric acid). The mechanism is described in all text books of organic chemistry as involving an alkyl migration. Here I take a look at the scheme described by Alvarez-Idaboy, Reyes and Mora-Diez[1], and which may well not yet have made it to all the text books!

The text-book mechanism involves pathway (a, R=CF3) via species 1 and 2. A characteristic feature of many a mechanism of this type is the need for a step often labelled just PT (proton transfer). Very often, a proton will find itself attached to the wrong atom, and before the mechanism can be completed, it must be transferred to the correct location. Confusingly, there can be many ways of doing this, differing in the timing of the proton choreography. Deciding that running order can be perplexing to new students of chemistry. Tutors often will say that since PTs are very fast, it does not matter when this step occurs, since in effect all paths will lead to the final product. But we might imagine that the energies of all the various pathways can be (in principle) obtained from quantum calculations and that one will prevail over the others.

Path (b) is just one such variation, but with a twist, since it involves starting from 3 and proceeding via a cyclic transition state in which the migrating alkyl group (shown in red above) moves in concert with the relocating proton. I have repeated the original calculations (from 2007) using a somewhat updated procedure, much in the same way that the transition state for the aldol reaction was. A ωB97XD/6-311G(d,p)/SCRF=dichloromethane calculation of step (b) gives the transition state and associated intrinsic reaction coordinate (IRC) shown below.

Cyclic 7-ring mechanism for the Baeyer-Villiger. Click for 3D.

IRC for 7-ring TS, forward direction only.

Choreographically, this transition state is quite complex. Five bonds, all different in some aspect, are changing in asynchronous concert.

  1. Following the transition state towards the product, between IRC=0 and +4, we see the cleavage of the O-O bond occurring in synchrony with the migration of the alkyl (methyl) group towards the oxygen (think of it as an SN2 reaction at oxygen). Notice the antiperiplanar stereoelectronic alignment of the migrating (methyl) and the axis of the O-O bond, which strongly differentiates which of the two alkyl groups migrates. The non-migrating group is essentially orthogonal to the O-O bond.
  2. At IRC = +5 we see a sudden abrupt feature, which corresponds to transfer of the proton, and which is complete by IRC = +6. Protons, being light, do tend to move quickly when they decide to.
  3. The final noteworthy feature from IRC=+6 to >20 is the rotation of the newly formed methoxy group, starting from orthogonality with the carbonyl group (~IRC +6) to co-planarity (IRC > 20). The origins of this effect are associated with the same orthogonal/antiperiplanar stereoelectronic alignments that determined which alkyl group migrated earlier.
  4. Notice a minor feature, which is the rotation of the methyl groups to set up weaker stereoelectronic interactions.

Path (c) is another variation, where an extra molecule of acid (X1, 4) helps catalyse the reaction, this time by creating an 11-membered ring 4 leading to a transition state with potentially two proton transfers as well as the alkyl migration. By involving an additional second molecule of acid as catalyst, we now have seven participating bond changes. Whilst the original path (b) six endo and two exo electrons move in a cycle which is tantalisingly close to but not quite pericyclic (?), path (c) extends this by four electrons. It might be tempting to try to apply a selection rule here (such as 4n+2) but I am not sure it would be justified. 

Baeyer-Villiger, 11-ring transition state. Click for 3D

  1. IRC +3 represents the starting tetrahedral intermediate 4 hydrogen bonded to an extra (trifluoroacetic) acid molecule.
  2. The transition state occurs at IRC =0.
  3. By IRC -2, O-O cleavage and methyl migration are essentially complete, but no protons have moved.
  4. From IRC -2 to -5, the methoxy group rotates to adopt the planar conformation of an ester.
  5. Only after this rotation does the first proton transfer start, at IRC -6, and this is then followed in rapid succession by a second at  -7 to complete the reaction to form ethyl ethanoate and two molecules of (trifluoroacetic) acid. This is a reversal of the sequence seen with path (b). Because no intermediates are discernible in the IRC, one must describe this as a concerted rearrangement, but in fact the bond choreography is far from synchronous. This is one aspect which conventional  arrow pushing does not capture.

To directly compare the energies of paths (b) and (c), we can repeat (b) with the addition of a more passive acid catalyst, in four new positions 3, X2 – X5. None of these are lower than 4 itself. There is one more surprise. Species 1 is not actually a minimum, but rearranges to e.g. the cyclic ring shown below. Its free energy is still higher than that of 3.

I will end with the following speculation. The point of interest to most students of the Baeyer-Villiger reaction is not the nature of the actual transition state, but deciding which of the two possible alkyl groups will migrate (in the example above both are methyls, but if one were e.g. phenyl it would migrate in preference to the methyl). The transition state teaches us that the group antiperiplanar to the O-O bond migrates. Can a system be devised where the antiperiplanar preference takes precedence over the migratory aptitude? For example, based on the following (click to see 3D structure below in which one R group is clearly pre-disposed to migrate in preference to the other).

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  1. J.R. Alvarez-Idaboy, L. Reyes, and N. Mora-Diez, "The mechanism of the Baeyer–Villiger rearrangement: quantum chemistry and TST study supported by experimental kinetic data", Org. Biomol. Chem., vol. 5, pp. 3682, 2007.

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5 Responses to “The mechanism of the Baeyer-Villiger rearrangement.

  1. [...] Henry Rzepa Chemistry with a twist « The mechanism of the Baeyer-Villier rearrangement. [...]

  2. Christian says:

    Professor Henry Rezpa,

    Just a couple of very naïve questions:

    Why would phenyl migrate in preference to the methyl? And the hydrogen in relation to these two?

    And can the molecular weight of a substituent influence the rate at which it migrates, if we could disregard the stabilization or not of the intermediary state due to its electronic properties? The logic (or not) is that hydrogen would migrate faster…

    Thank you very much.

  3. Henry Rzepa says:

    The accepted wisdom for the greater migratory aptitude of phenyl is that the transition state can adopt a spiro-coordination where delocalisation into the pentadienyl part of the phenyl brings additional stabilisation.

    As for H, being light as you say, it can also tunnel in a manner that heavier groups cannot. Classical transition state theory does not include the weight of the groups involved, excepting that this will impact upon their entropy. But it is increasingly recognised that the molecular dynamics of the system has a significant role to play, and more and more examples are coming to light where such dynamics does indeed control the outcome.

  4. [...] non-hydrogen atoms and those involving reorganisation of proximate hydrogens. The Baeyer-Villiger discussed previously illustrated a complex dance between the two types. Here I take a look at another such mechanism, [...]

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