I am exploring the fascinating diverse facets of a recently published laboratory experiment for undergraduate students.[cite]10.1021/acs.jchemed.7b00566[/cite] Previously I looked at a possible mechanistic route for the reaction between an enal (a conjugated aldehyde-alkene) and benzyl chloride catalysed by base and a chiral amine, followed by the use of NMR coupling constants to assign relative stereochemistries. Here I take a look at some chiroptical techniques which can be used to assign absolute stereochemistries (configurations).
Posts Tagged ‘Isomer’
Organocatalytic cyclopropanation of an enal: (computational) assignment of absolute configurations.
Saturday, September 1st, 2018Bond stretch isomerism. Did this idea first surface 100 years ago?
Tuesday, February 9th, 2016The phenomenon of bond stretch isomerism, two isomers of a compound differing predominantly in just one bond length, is one of those chemical concepts that wax and occasionally wane.[cite]10.1016/S1631-0748(02)01380-2[/cite] Here I explore such isomerism for the elements Ge, Sn and Pb.