Posts Tagged ‘energy profile’

Patterns of behaviour: serendipity in action for enantiomerisation of F-S-S-Cl

Thursday, September 19th, 2013

Paul Schleyer sent me an email about a pattern he had spotted, between my post on F3SSF and some work he and Michael Mauksch had done 13 years ago with the intriguing title “Demonstration of Chiral Enantiomerization in a Four-Atom Molecule“.[1] Let me explain the connection, but also to follow-up further on what I discovered in that post and how a new connection evolved.FSSF3-gen

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References

  1. P.V.R. Schleyer, and M. Mauksch, "Demonstration of Chiral Enantiomerization in a Four‐Atom Molecule ", Angewandte Chemie International Edition, 2000. http://doi.org/d8g2nw

A conflation of concepts: Conformation and pericyclic.

Thursday, January 10th, 2013

This is an interesting result I got when studying the [1,4] sigmatropic rearrangement of heptamethylbicyclo-[3.1.0]hexenyl cations. It fits into the last lecture of a series on pericyclic mechanisms, and just before the first lecture on conformational analysis. This is how they join.

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Secrets of a university tutor. An exercise in mechanistic logic: second dénouement.

Monday, October 29th, 2012

Following on from our first mechanistic reality check, we now need to verify how product A might arise in the mechanism shown below, starting from B.

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