Archive for June 1st, 2017

Tautomeric polymorphism.

Thursday, June 1st, 2017

Conformational polymorphism occurs when a compound crystallises in two polymorphs differing only in the relative orientations of flexible groups (e.g. Ritonavir).[1] At the Beilstein conference, Ian Bruno mentioned another type;  tautomeric polymorphism, where a compound can crystallise in two forms differing in the position of acidic protons. Here I explore three such examples.

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References

  1. G.J.O. Beran, I.J. Sugden, C. Greenwell, D.H. Bowskill, C.C. Pantelides, and C.S. Adjiman, "How many more polymorphs of ROY remain undiscovered", Chemical Science, vol. 13, pp. 1288-1297, 2022. http://dx.doi.org/10.1039/D1SC06074K