 |
Mechanism:
- Kinetic studies establish the
rate limiting step as ...
- the eneamine presenting its re or si π-face
- to the re or si carbonyl π-face
- to form a new C-C bond
Choreography:
- C-C bond formation vs
- Proton transfer?
Catalytic Cycle:
- The proline is regenerated (fast)
- and can be recovered unchanged at the end.
|