"The underlying physical laws necessary for the mathematical theory of a large part of physics and the whole of chemistry are thus completely known, and the difficulty is only that the exact
application of these laws leads to equations
much too complicated to be soluble."
"It therefore becomes desirable that approximate practical methods of applying quantum mechanics should be developed,
which can lead to an explanation of the main features of
complex atomic systems without too much computation."
2014: How much computation is needed to explain stereochemical outcomes (of organocatalytic reactions)