Posts Tagged ‘text-book author’

Oxime formation from hydroxylamine and ketone: a (computational) reality check on stage one of the mechanism.

Sunday, September 23rd, 2012

The mechanism of forming an oxime from nucleophilic addition of a hydroxylamine to a ketone is taught early on in most courses of organic chemistry. Here I subject the first step of this reaction to form a tetrahedral intermediate to quantum mechanical scrutiny.