Linear free energy relationships (LFER) are associated with the dawn of physical organic chemistry in the late 1930s and its objectives in understanding chemical reactivity as measured by reaction rates and equilibria.
Henry Rzepa's Blog
Chemistry with a twist
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- Mechanism of the reduction of a carboxylic acid by borane: revisited and revised.
- Oxime formation from hydroxylamine and ketone: a (computational) reality check on stage one of the mechanism.
- Why are α-helices in proteins mostly right handed?
- Why is the carbonyl IR stretch in an ester higher than in a ketone?
- The mechanism of the Benzidine rearrangement.
- VSEPR Theory: A closer look at chlorine trifluoride, ClF3.
- Reductive ozonolysis: the interesting step.
- Surprises (?) in the addition of HCl to a carbonyl group.
- The mechanism of diazo coupling: more hidden mechanistic intermediates.
- The chemistry of scents: Vetifer oil.
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Recent Posts
- The chemistry of scents: Vetifer oil.
- Non-covalent-interaction (NCI) surfaces for two large annulenes (revisited).
- The thermal reactions … took precisely the opposite stereochemical course to that which we had predicted. A non-covalent-interaction view of the model.
- The Stevens rearrangement: how history gives us new insights.
- The chemical synthesis of C2: another fascinating twist to the story.
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- Nick Davies on The chemistry of scents: Vetifer oil.
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- Thomas Perks on Chemistry in the early 1960s: a reminiscence.
- wendy on The Willgerodt-Kindler Reaction: mechanistic reality check 1.
- Henry Rzepa on The Willgerodt-Kindler Reaction: mechanistic reality check 1.
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- https://ojs.uv.es/ on The Amsterdam Manifesto on Data Citation Principles
- Henry Rzepa on Is cyanogen chloride (fluoride) a source of C⩸N(+)? More mechanistic insights.
- look@as on Is cyanogen chloride (fluoride) a source of C⩸N(+)? More mechanistic insights.
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Henry Rzepa
Emeritus Professor of computational chemistry, Imperial College London. http://orcid.org/0000-0002-8635-8390
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