Posts Tagged ‘free energy barrier&nbsp’

I’ve started so I’ll finish. Mechanism and kinetic isotope effects for protiodecarboxylation of indoles.

Saturday, January 2nd, 2016

Another mechanistic study we started in 1972[1] is here 40+ years on subjected to quantum mechanical scrutiny.



  1. B.C. Challis, and H.S. Rzepa, "Heteroaromatic hydrogen exchange reactions. Part 9. Acid catalysed decarboxylation of indole-3-carboxylic acids", Journal of the Chemical Society, Perkin Transactions 2, pp. 281, 1977.