Linear free energy relationships (LFER) are associated with the dawn of physical organic chemistry in the late 1930s and its objectives in understanding chemical reactivity as measured by reaction rates and equilibria.
Posts Tagged ‘Electrophilic aromatic substitution’
Free energy relationships and their linearity: a test example.
Sunday, January 13th, 2019A new way of exploring the directing influence of (electron donating) substituents on benzene.
Friday, April 17th, 2015The knowledge that substituents on a benzene ring direct an electrophile engaged in a ring substitution reaction according to whether they withdraw or donate electrons is very old.[cite]10.1039/CT8875100258[/cite] Introductory organic chemistry tells us that electron donating substituents promote the ortho and para positions over the meta. Here I try to recover some of this information by searching crystal structures.