Mechanistic templates computed for the Grubbs alkene-metathesis reaction.

February 19th, 2024

Following on from my template exploration of the Wilkinson hydrogenation catalyst, I now repeat this for the Grubbs variant of the Alkene metathesis reaction. As with the Wilkinson, here I focus on the stereochemistry of the mechanism as first suggested by Chauvin[cite]https://doi.org/10.1002/macp.1971.021410112[/cite], an aspect lacking in eg the Wikipedia entry. As before, the diagram below is hyperlinked to the appropriate data repository identifier so that you can go straight from the scheme to the data (Top level Data DOI: 10.14469/hpc/13796).

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3D Molecular model visualisation: 3 Million atoms +

January 27th, 2024

In the late 1980s, as I recollected here[cite]10.59350/g4j62-4xk50[/cite] the equipment needed for real time molecular visualisation as it became known as was still expensive, requiring custom systems such as Evans and Sutherland PS390 workstations. One major breakthrough in making such techniques generally available on less specialised equipment was achieved by Roger Sayle[cite]10.1016/s0968-0004(00)89080-5[/cite], then working at Imperial College around 1990 and using a Silicon Graphics workstation. He greatly optimised up the rendering algorithms by creating a program called RasMol (after his initials), which meant such visualisations could very rapidly also be achieved even on a personal computer. Moving from vector display technology (the PS390) to Raster/bitmap graphics had allowed spacefilling representations of molecules containing 100s if not 1000s of atoms – and in turn enabled the new World-Wide Web to exploit the technique.[cite]10.1039/C39940001907[/cite]

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The Macintosh computer at 40.

January 25th, 2024

On 24th January 1984, the Macintosh computer was released, as all the media are informing us. Apparently, some are still working. I thought I would give my own personal recollections of that period.

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A mechanistic exploration of the Wilkinson hydrogenation catalyst. Part 1: Model templates

January 21st, 2024

Geoffrey Wilkinson first reported his famous work on the hydrogenation catalyst that now bears his name in 1965[cite]10.1039/C19650000131[/cite] and I met him at Imperial College around 1969 and again when I returned there in 1977. He was still working on these catalysts then and I was privileged to collaborate with him on unravelling the NMR spectra of some of these compounds.[cite]10.1039/C39820000482[/cite],[cite]10.1016/S0277-5387(00)86558-4[/cite],[cite]10.1016/0277-5387(82)80008-9[/cite]. During that period, computational modelling of the mechanisms of molecules containing transition elements was still in its infancy and I never extended my collaboration into this area at that time. Now, even if belatedly, I decided to explore this aspect and started to do this about two weeks ago. Here I thought that I would use this opportunity to show how I am going about it.

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Scholarly journals vs Scholarly Blogs.

January 12th, 2024

First, a very brief history of scholarly publishing, starting in 1665[cite]10.1098/rstl.1665.0001[/cite] when scientific journals started to be published by learned societies. This model continued until the 1950s, when commercial publishers such as Pergamon Press started with their USP (unique selling point) of rapid time to publication of ~3 months,[cite]10.1016/0040-4020(57)85003-0[/cite] compared to typical times for many learned society publishers of 2 years or longer. Fast forward another 50 years or so, and the commercial publishers were now dominating the scene, but the business model was still based on institutional subscriptions, whereby the institution rather than authors paid the costs of publication. As the number of journals expanded, even well-off institutions had to make difficult decisions on which subscriptions to keep and which to cancel. By the late 1990s the delivery model was changing from print to online, but the overall issue was that many scientists around the world no longer had access to many journals.

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Macrocyclic peptide antibiotics – now Zosurabalpin – then antibacterial agents based on cyclic D,L-α-peptide architectures.

January 8th, 2024

Zosurabalbin[cite]10.1038/s41586-023-06873-0[/cite],[cite]10.1093/ofid/ofad500.1754[/cite], is receiving a great deal of attention as a new class of antibiotic which can target infections for which current treatment options are inadequate. It is a cyclic peptide and seeing this triggered memory of an earlier such species reported way back in 1995[cite]10.1002/anie.199500931[/cite],[cite]10.1038/35086601[/cite]. This octa-peptide (YIJDIE, DOI: 10.5517/cc58gxs) was presumed to function in a novel manner, having linear water channels wide enough to form a molecular nanoscale pipe for a stream of water molecules to flow along. When inserted into the bacterial cell membrane via its lipophilic sidechains, it drained the bacterium of its cell water within seconds, thus killing it. A 3D model shows the effect very clearly.

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Molecules of the year 2023 – part 2. A FAIR data comment on a Strontium Metallocene.

December 29th, 2023

I will approach this example of a molecule-of-the-year candidate – in fact the eventual winner in the reader poll – from the point of view of data. Its a metallocene arranged in the form of a ring comprising 18 sub-units.[cite]10.1038/s41586-023-06192-4[/cite] Big enough to deserve a 3D model rather than the static images you almost invariably get in journals (and C&EN). So how does one go to the journal and acquire the coordinates for such a model?

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Molecules of the year: 2023

December 28th, 2023

The Science education unit at the ACS publication C&EN publishes its list of molecules of the year (as selected by the editors and voted upon by the readers) in December. Here are some observations about three of this year’s batch. Read the rest of this entry »

The journey from Journal “ESI” to FAIR data objects: An eighteen year old (continuing) experiment.

December 10th, 2023

Around 1996, journals started publishing what became known as “ESI” or electronic supporting information, alongside the articles themselves, as a mechanism for exposing the data associated with the research being reported and exploiting some of the new opportunities offered by the World Wide Web. From the outset, such ESI was expressed as a paginated Acrobat file, with the Web being merely a convenient document delivery mechanism. Such ESI would eventually reach more than 1000 such pages in length in some chemistry articles. The richer opportunities of Web interactivity were far less exploited. I have written about various aspects of this throughout this blog[cite]10.59350/qypm4-qfv97[/cite],[cite]10.59350/cqesx-a0e83[/cite],[cite]10.59350/z9g5j-r2p69[/cite], together with one early compendium of our own data examples.[cite]10.59350/wczky-8sf79[/cite] Here I update that compendium starting from 2005 to the current 2023 and add further information, being the current state of curation of some of these early examples. Curation became necessary because many of the earlier examples were no longer functional due to changes in the way journals expose these data objects or indeed changes at the data repository end of things over this 18 year period.

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A trip down memory lane: An online departmental connection map from 1989.

December 7th, 2023

In 2023, we very much take for granted that everyone and pretty much everything is online. But it was not always so and when I came across an old plan indicating how the chemistry department at Imperial College was connected in 1989, I was struck by how much has happened in the 34 years since. Nowadays all the infrastructures needed are effectively “built in” to the building when it is constructed and few are even aware of them. But in 1989 that was not at all true.

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