Derek Lowe highlights a recent article[1] postulating CH⋅⋅⋅π interactions in proteins. Here I report a quick check using the small molecule crystal structure database (CSD).
The search query (DOI: 10.14469/hpc/2594) is shown below.
The two most interesting hits, both revealing short distances and ~orthogonal approaches to the π-system are:
Remember however that such “outliers” must always be carefully inspected. There are more numerous interactions in the region 2.4-2.6Å with a sine(angle) of >0.9 and and a close orthogonal approach to the π-system (green dots) which probably qualify for the title above. There seem many interesting but still putative small-molecule candidates for this proposed interaction postulated for proteins.
Postscript: Here the results of the search above with R= any of H,C,N,O,F,Cl up to values of the distance <2.4Å, which show a range of interesting (green) points.
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Indeed interesting...
Here are plots with OH and NH replacing CH interactions.
Note that sine(angle)