Archive for March 29th, 2020

Substituent effects on the mechanism of Michael 1,4-Nucleophilic addition.

Sunday, March 29th, 2020

In the previous post, I looked at the mechanism for 1,4-nucleophilic addition to an activated alkene (the Michael reaction). The model nucleophile was malonaldehyde after deprotonation and the model electrophile was acrolein (prop-2-enal), with the rate determining transition state being carbon-carbon bond formation between the two, accompanied by proton transfer to the oxygen of the acrolein.