Archive for January, 2018
Tuesday, January 23rd, 2018
Another occasional conference report (day 1). So why is one about “persistent identifiers” important, and particularly to the chemistry domain?
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Tags:Academic publishing, Andy Mabbett, Chemical IT, Digital Object Identifier, Identifiers, Imperial College, Index, Information science, Johanna McEntyre, Knowledge, Mark Hahnel, ORCiD, Persistent identifier, Publishing, Quotation, researcher, Scholarly communication, SciCrunch, search engines, Technical communication, Technology/Internet, Tom Gillespie
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Sunday, January 14th, 2018
I don’t normally write about the pharmaceutical industry, but I was intrigued by several posts by Derek Lowe (who does cover this area) on the topic of creating new drugs by deuterating existing ones. Thus he covered the first deuterated drug receiving FDA approval last year, having first reviewed the concept back in 2009. So when someone introduced me to sila-haloperidol, I checked to see if Derek had written about it. Apparently not, so here are a few details.
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Tags:Chemistry, Derek Lowe, Deuterated drug, Drug, drug design, FDA, Food and Drug Administration, General, Haloperidol, Health, Health/Medical/Pharmaceuticals, HTC HD2 Smartphone, metabolic products, Pharmaceutical industry, Pharmacy, physico-chemical profiles, United States Public Health Service
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Saturday, January 13th, 2018
I discussed the molecule the molecule CH3F2- a while back. It was a very rare computed example of a system where the added two electrons populate the higher valence shells known as Rydberg orbitals as an alternative to populating the C-F antibonding σ-orbital to produce CH3– and F–. The net result was the creation of a weak C-F “hyperbond”, in which the C-F region has an inner conventional bond, with an outer “sheath” encircling the first bond. But this system very easily dissociates to CH3– and F– and is hardly a viable candidate for experimental detection. In an effort to “tune” this effect to see if a better candidate for such detection might be found, I tried CMe3F2-. Here is its story.
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Tags:Antibonding molecular orbital, candidate for experimental detection, chemical bonding, chemical shift, Chemistry, Hypervalency, metal, Molecular orbital, Nature
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Saturday, January 6th, 2018
The title here is from an article on metalenses[1] which caught my eye.
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References
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M. Khorasaninejad, W.T. Chen, A.Y. Zhu, J. Oh, R.C. Devlin, D. Rousso, and F. Capasso, "Multispectral Chiral Imaging with a Metalens", Nano Letters, vol. 16, pp. 4595-4600, 2016. http://dx.doi.org/10.1021/acs.nanolett.6b01897
Tags:Biochemistry, Biology, Chemistry, Chirality, Circular dichroism, Interesting chemistry, Nature, Pharmacology, Polarization, spectroscopy, Stereochemistry, Ultraviolet, Vibrational circular dichroism
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