Posts Tagged ‘suitable molecular modelling software’

Updating a worked problem in conformational analysis. Part 1: the question.

Friday, May 13th, 2011
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Conformational analysis comes from the classical renaissance of physical organic chemistry in the 1950s and 60s. The following problem is taken fromĀ E. D. Hughes and J. Wilby J. Chem. Soc., 1960, 4094-4101, DOI: 10.1039/JR9600004094, the essence of which is that Hofmann elimination of a neomenthyl derivative (C below) was observed as anomalously faster than its menthyl analogue. Of course, what is anomalous in one decade is a standard student problem (and one Nobel prize) five decades later.

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