Posts Tagged ‘nucleophilic attack’

Oxime formation from hydroxylamine and ketone: a (computational) reality check on stage one of the mechanism.

Sunday, September 23rd, 2012
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The mechanism of forming an oxime from nucleophilic addition of a hydroxylamine to a ketone is taught early on in most courses of organic chemistry. Here I subject the first step of this reaction to form a tetrahedral intermediate to quantum mechanical scrutiny.

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